![]() ![]() Normal value excludes primary hypothyroidism and a markedly elevated value confirms the diagnosis. Thyroid-stimulating hormone (TSH) assay result is >4.0 mU/L ( normal values: 0.5–1.5 mU/L).Activity intolerance related to weakness and apathy.Symptoms and signs of myxedema coma include: It may be caused by an infection, illness, exposure to cold, or certain medications in people with untreated hypothyroidism. Myxedema coma, the most severe form of hypothyroidism, is rare. Cardiac enlargement, tendency to develop congestive heart failure.Generalized puffiness and edema around the eyes and face.Hashimoto’s disease is common in the same family and is considered an autoimmune disorder leading to chronic inflammation of the thyroid gland and hypothyroidism but can also lead to hyperthyroidism. The most common cause of goitrous hypothyroidism in North America is Hashimoto’s disease, which causes defective iodine binding and defective thyroid hormone production.Tertiary hypothyroidism is caused by failure of the hypothalamus to produce thyroid-releasing factor. Secondary hypothyroidism, which occurs in only 5% of cases, is caused by a failure of the pituitary gland to stimulate the thyroid gland or a failure of the target tissues to respond to the thyroid hormones.It is most frequently autoimmune in origin but can also be related to iodine deficiency. In most cases, hypothyroidism occurs as a primary disorder and results from the loss of thyroid tissue, which leads to inadequate production of thyroid hormones (primary hypothyroidism). ![]() Hypothyroidism can be a primary disorder that results from disease in the thyroid gland itself or a secondary or tertiary disorder.Hypothyroidism is characterized by decreased rate of body metabolism.Hypothyroidism is a hypothyroid state resulting from a hyposecretion of the thyroid hormones T4 and T3. ![]()
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